Sleep

Terpinolene

Terpinolene has been shown to exhibit antioxidant and anticancer effects in rat brain cells. Studies with mice show that terpinolene has a sedative effect when inhaled. In addition, terpinolene is responsible for many of the floral notes found in Jack Herer varieties.

Trahydrocannabinolic Acid

You’ve heard of THC, and while they may sound similar, THCA has very different properties. Unlike THC, THCA is a non-intoxicating cannabinoid found in raw and live cannabis.

Here are some of the potential benefits studies have started to unveil:

  • Anti-inflammatory properties for treatment of arthritis and lupus
  • Neuroprotective properties for treatment of neurodegenerative diseases
  • Anti-emetic properties for treatment of nausea and appetite loss
  • Anti-proliferative properties noted in studies of prostate cancer
  • Other possible medicinal avenues supported by patient stories include insomnia, muscle spasms, and pain.

Tetrahydrocannabinol

The most abundant cannabinoid present in marijuana, THC is responsible for cannabis’ most well-known psychoactive effects. THC acts as a partial agonist at the CB1 and CB2 receptors. The compound is a mild analgesic, or painkiller, and cellular research and shown that it has antioxidant activity.

Other research has noted that THC also interacts with receptors in the hypothalamus of the brain – possibly releasing the hormone ghrelin, which is in charge of stimulating hunger.

By manipulating this pathway and the olfactory bulb simultaneously, THC can “trick” the brain into thinking it’s hungry. It does this by mimicking the sensations the brain and body feel when hungry, through manipulation of the proopiomelanocortin (POMC).

The POMC refers to the neurons in the hypothalamus that tell the body when it’s full. Scientists in a 2015 study led by Tamas Horvath of Yale discovered that not only did THC fail to turn off the POMC, it actually flipped its function.

Under the influence of THC, the POMC does not tell the body that it’s full, but rather that it’s hungry. Therefore, the body experiences all the same feelings of hunger, along with an enhanced sense of smell and taste. It’s no wonder marijuana creates the perfect storm for stimulating appetite.

Cannabidiol

CBD is a natural chemical derived from the cannabis plant. The compound belongs to a classification known as cannabinoids, which are found both in cannabis (phytocannabinoids) and the human body (endocannabinoids).

Your body has an endocannabinoid system, which in short means that it has receptors for cannabinoid compounds like CBD and THC. CBD and THC both interact with the body through the endocannabinoid system, a biological communication system that regulates a wide array of functions, like:

• Pain
• Appetite
• Mood
• Memory
• Immune response
• Sleep

CBD and THC have chemical structures similar to the body’s own endocannabinoids, which allows them to interact with the endocannabinoid system’s cannabinoid receptors.

The main difference between CBD and THC? THC causes euphoria and other mind-altering effects, CBD doesn’t. Not even a little bit. Also, THC is in high quantities in marijuana, and CBD is abundant in hemp.

Cannabinol

CBN is a mildly psychoactive cannabinoid that is produced from the degradation of THC. There is usually very little to no CBN in a fresh plant. CBN acts as a weak agonist at both the CB1 and CB2 receptors, with greater affinity for CB2 receptors than CB1. The degradation of THC into CBN is often described as creating a sedative effect, known as a “couch lock.”